The purpose of this best practice guideline is to provide evidence-informed recommendations for individuals, systems, and organizations to identify and describe: practices that result in preventing and mitigating fatigue for nurses and other health-care professionals; System resources that support practices to prevent fatigue; organizational cultures, values andresources that support effective practices to prevent fatigue; personal resources that can be used to prevent or mitigate fatigue; and anticipated outcomes when fatigue is effectively managed, thereby fostering healthy work environme